IFIH1 Interferon-Induced Helicase

A DEAD box RNA helicase that contains two N-terminal CASPASE ACTIVATION AND RECRUITMENT DOMAINS. It functions as a sensor of viral NUCLEIC ACIDS such as DOUBLE-STRANDED RNA and activates the INNATE IMMUNE RESPONSE by inducing the expression of INTERFERON-ALPHA and INTERFERON-BETA. It may also regulate cell growth and APOPTOSIS.

Also Known As:

Interferon-Induced Helicase, IFIH1; CADM-140 Autoantigen; Helicard; IFIH1 Protein; Interferon Induced with Helicase C Domain 1; Interferon-Induced Helicase C Domain-Containing Protein 1; Melanoma Differentiation-Associated Protein 5; Autoantigen, CADM-140; CADM 140 Autoantigen; Helicase, IFIH1 Interferon-Induced; Interferon Induced Helicase C Domain Containing Protein 1; Interferon Induced Helicase, IFIH1; Melanoma Differentiation Associated Protein 5

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Nucleotidyltransferases: 31
        RNA Nucleotidyltransferases
        RNA Helicases: 503
        DEAD-box RNA Helicases: 122
        IFIH1 Interferon-Induced Helicase: 148
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Antiviral Restriction Factors: 92
    - IFIH1 Interferon-Induced Helicase: 148

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Disease

Drug/Important Bio-Agent (IBA)